Sexual arousal

– stimulation triggers the release of nitric oxide.

Sexual arousal > Nitric oxide > Increased Blood flow > Erection

Link between Low Folic acid Erectile Dysfunction

Can low folic acid levels impact your capacity to gain and maintain an erection?

The latest meta-analysis or past research demonstrated that Folic Acid was an independent risk factor for erectile dysfunction.

Folic acid supplement may potentially have positive effects in the treatment of ED patients.

Folic acid

Folic acid is a member of the B-vitamin family and is essential for amino acid metabolism.

Folic acid  >  improves nitric oxide (NO) bioavailability by increasing endothelial NO synthase coupling.

By improving nitric oxide bioavailability, folic acid may protect or improve endothelial function

Endothelial dysfunction

Endothelial dysfunction, leads to an inability of the smooth muscle cells lining the arterioles to relax, preventing vasodilatation.

Penile erection depends on the relaxation of smooth muscle in the corpus cavernosum and the wall of small arteries.

Researchers found that endothelial function was impaired in erectile dysfunction patients with no apparent cardiovascular disease and diabetes mellitus.

L-Arginine vs L-Citrulline Supplements

Citrulline is found to be more effective at increasing Nitric Oxide synthesis

L-Citrulline supplementation during endotoxemia and not L-Arginine reduced intestinal microcirculatory dysfunction and increased intracellular NO production, likely via increased intracellular citrulline and arginine availability.

Citrulline supplementation is more efficient at increasing arginine availability than is arginine in mice.

• Nitric Oxide production diminishes as we age